HD Blog

This is the first study to show exercise raising GDNF and in turn protecting neural cells. However, there's been at least eight other studies to indicate that raised GDNF levels can protect the brain from Huntington's damage.

Here's the study:

Exp Neurol. 2003 Nov;184(1):31-9.
Can the brain be protected through exercise? Lessons from an animal model of parkinsonism small star, filled.

Smith AD, Zigmond MJ.

Departments of Neurology and Psychiatry, Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh School of Medicine, 15217, Pittsburgh, PA, USA

Evidence suggests that following injury the brain has the capacity for self-repair and that this can be promoted through a variety of experiences including motor activity. In their article, Dobrossy and Dunnett have provided further evidence that this is the case in an animal model in which an excitotoxin is applied to the neostriatum. Under standard conditions, such a toxin would cause considerable damage to the GABAergic cells of this region and produce behavioral deficits. This model has been used to explore certain aspects of Huntington's disease, which also involves the loss of these neurons. However, Dobrossy and Dunnett show that the damage can be reduced by prior motor training. We have been exploring the neuroprotective effects of motor exercise in a different model, one involving 6-hydroxydopamine, which normally destroys dopamine neurons. Our results indicate that forced exercise can reduce the vulnerability of dopamine neurons to 6-hydroxydopamine. The results further suggest that this protection is due in part to an increase in the availability of the trophic factor GDNF, which can in turn stimulate certain signaling cascades, including one that activates ERK. Our results, together with those of Dobrossy and Dunnett and others, raise the possibility that exercise will protect against a variety of neurodegenerative conditions.

PMID: 14637076 [PubMed - in process]