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October 13, 2004
Rethinking Huntington's Disease
This study could have profound implications in the future of HD research. If this turns out to be true, this will help further focus research.
Read the article, but here's an excerpt:
He also points out that the aggregation of huntingtin might still play a detrimental role in the disease. But the extremely large protein clumps that form inclusion blobs appear to be a sign of cells fighting back, he says.
The result could change the development of HD therapy. Researchers are already looking for drugs that keep huntingtin from aggregating. But some of these drugs might prevent the formation of protective inclusion bodies while allowing the smaller – and possibly lethal - groups of huntingtin to form. "One prediction of ours is that some of these drugs could actually make the disease worse," he says.
Posted by Dave at October 13, 2004 11:25 AM
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