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November 10, 2004
RNAi Takes Another Step Forward
They've now been able to lower cholesterol in animal tests with RNAi. Some tidbits from the latest article:
It ultimately could lead to a drug-like treatment for hereditary disorders such as Huntington's disease by injecting tailored snippets of RNA, DNA'S molecular cousin, to silence a specific gene. The approach also has promise for treating a range of diseases, including heart disease and cancer, that have genetic factors, specialists said. ...
The new study, published Thursday in the journal Nature, reports successful delivery of RNA pieces through the blood by chemically stabilizing them and attaching them to cholesterol molecules to help ease their entry into target cells. ...
RNA interference "has major potential for discovery and development of new medicines," said Nobel laureate Philip Sharp, a molecular biologist at the Massachusetts Institute of Technology and a co-founder of Alnylam. "It is the type of discovery that really only happens every decade or so."
Posted by Dave at November 10, 2004 09:02 PM
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