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April 01, 2005
Another Potential Treatment Option
Researchers have found that an enzyme that helps cells dispose of unwanted proteins may actually protect against a class of inherited brain disorders that includes Huntington's disease. ,,,"Then, we thought that maybe we could reveal a disease phenotype if we expressed normal ataxin-3 together with the pathogenic protein. Maybe we would see an enhancement or synergy of the pathology. But what happened, quite surprisingly, is that the normal ataxin-3 dramatically suppressed the disease. That says that the normal function of the pathogenic protein can help mitigate its own toxicity." ...
Importantly, when the researchers introduced ataxin-3 into fly models of other polyglutamine diseases, including Huntington's disease, they found a similar protective effect.
More at Medical News Today.
Posted by Dave at April 1, 2005 05:19 AM
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